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Mystery as eye cancer cluster strikes young women within 25 miles of North Carolina town! Researchers vainly search for environmental or genetic links

&Tab;&Tab;<div class&equals;"wpcnt">&NewLine;&Tab;&Tab;&Tab;<div class&equals;"wpa">&NewLine;&Tab;&Tab;&Tab;&Tab;<span class&equals;"wpa-about">Advertisements<&sol;span>&NewLine;&Tab;&Tab;&Tab;&Tab;<div class&equals;"u top&lowbar;amp">&NewLine;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;&Tab;<amp-ad width&equals;"300" height&equals;"265"&NewLine;&Tab;&Tab; type&equals;"pubmine"&NewLine;&Tab;&Tab; data-siteid&equals;"109460728"&NewLine;&Tab;&Tab; data-section&equals;"1">&NewLine;&Tab;&Tab;<&sol;amp-ad>&NewLine;&Tab;&Tab;&Tab;&Tab;<&sol;div>&NewLine;&Tab;&Tab;&Tab;<&sol;div>&NewLine;&Tab;&Tab;<&sol;div><div class&equals;"billboard&lowbar;wrapper relative"><&sol;div>&NewLine;<div>&NewLine;<div class&equals;"articleWide cleared">&NewLine;<div class&equals;"alpha">&NewLine;<div id&equals;"js-article-text" class&equals;"article-text wide ">&NewLine;<h6><span style&equals;"color&colon; &num;080000&semi;"><strong>15 <&sol;strong><&sol;span><span style&equals;"color&colon; &num;080000&semi;"><strong>women mostly<&sol;strong><&sol;span><span style&equals;"color&colon; &num;080000&semi;"><strong> in their 30s or younger <&sol;strong><&sol;span><span style&equals;"color&colon; &num;080000&semi;"><strong>are diagnosed with disease that only affects five in every million in a 25-mile area<&sol;strong><&sol;span><&sol;h6>&NewLine;<h6><span style&equals;"color&colon; &num;080000&semi;"><strong>The <&sol;strong><&sol;span><span style&equals;"color&colon; &num;080000&semi;"><strong>eye cancer cluster has been diagnosed in nearly two dozen people in a 15-mile radius surrounding Huntersville&comma; North Carolina<&sol;strong><&sol;span><&sol;h6>&NewLine;<h6><span style&equals;"color&colon; &num;080000&semi;"><strong>Patients develop ocular melanoma&comma; a form of eye cancer that is most common in men in their 60s<&sol;strong><&sol;span><&sol;h6>&NewLine;<h6><strong><span style&equals;"color&colon; &num;080000&semi;">Researchers are still searching for link but so far have not found any environmental or genetic cause<&sol;span><&sol;strong><span style&equals;"color&colon; &num;080000&semi;">s <&sol;span><&sol;h6>&NewLine;<div>&NewLine;<h6 class&equals;"mol-para-with-font"><img class&equals;"alignnone wp-image-287824" src&equals;"https&colon;&sol;&sol;konniemoments&period;com&sol;wp-content&sol;uploads&sol;2018&sol;01&sol;Jessica-Boesmiller-1&period;png" alt&equals;" Jessica Boesmiller 1&period;png" width&equals;"647" height&equals;"578" &sol;><strong>Jessica Boesmiller&comma; 37&comma; who lives five miles outside of Huntersville&comma; North Carolina&comma; was diagnosed with ocular melanoma in November while eight months pregnant with twins&comma; fortunately the twins are cancer free<&sol;strong><&sol;h6>&NewLine;<p>The unlikely scourge of a rare form of eye cancer has affected nearly two dozen people and killed four within a 25-mile radius of a North Carolina town over the last decade &&num;8211&semi; and experts have no idea what&&num;8217&semi;s causing it&period; The incidence has left the residents of Huntersville&comma; NC wondering why this rare form of eye cancer afflicted so many people in their town&period;<br &sol;>&NewLine;Ocular melanoma is diagnosed in about 2&comma;500 adults a year&comma; or 5 to 7&period;5 new cases in 1 million people&period; Victims are most often men&comma; and odds of getting it increase with age&period;  Contrary to the odds &comma; in Huntersville&comma; nine of the 12 victims who had lived&comma; worked or often visited the town before their diagnoses were female&period; Six were younger than 30 when diagnosed&period; Three patients had attended Hopewell High School&period; Four people have died&period;<br &sol;>&NewLine;The most recent case was discovered five miles away in November when a 37-year-old woman was diagnosed with the eye tumor while eight months pregnant&comma; leading to a complete removal of her eye&period;  Jessica Boesmiller who lives five miles outside of Huntersville&comma; North Carolina&comma; was diagnosed with ocular melanoma in November while eight months pregnant with twins&period;<br &sol;>&NewLine;The first cases of the disease that raised alarms came a decade ago when three women who had attended Hopewell High School in Huntersville were diagnosed in their 20s&period;<br &sol;>&NewLine;Kenan Koll was 23 when she began experiencing blurred vision and after new contacts and glasses could not fix her eyesight&comma; a trip to the ophthalmologist diagnosed her with ocular melanoma in February 2009&period;<&sol;p>&NewLine;<h6><img class&equals;"alignnone wp-image-287832" src&equals;"https&colon;&sol;&sol;konniemoments&period;com&sol;wp-content&sol;uploads&sol;2018&sol;01&sol;Kennan-Colbert-Koll-3&period;png" alt&equals;"Kennan Colbert Koll 3" width&equals;"651" height&equals;"821" &sol;><strong>Kenan Koll&comma; 28&comma; attended Hopewell High School in Huntersville&comma; North Carolina&comma; and were killed by ocular melanoma in 2014&period; Her parents are committed to helping r<&sol;strong><strong>esearchers hoping to find breakthrough for the <&sol;strong><strong>rare eye cancer<&sol;strong><&sol;h6>&NewLine;<div class&equals;"artSplitter mol-img-group">&NewLine;<div class&equals;"splitRight">&NewLine;<div class&equals;"mol-img">&NewLine;<h6 class&equals;"container-3zJLP vertical-2XJd5"><strong><img class&equals;"alignnone wp-image-287835" src&equals;"https&colon;&sol;&sol;konniemoments&period;com&sol;wp-content&sol;uploads&sol;2018&sol;01&sol;Meredith-Legg-4&period;png" alt&equals;"Meredith Legg 4&period;png" width&equals;"794" height&equals;"508" &sol;>Meredith Legg similarly <&sol;strong><strong>attended<&sol;strong><strong> Hopewell High School in Huntersville&comma; North Carolina&comma; and was killed by ocular melanoma in 2014 at the age of 26<&sol;strong><&sol;h6>&NewLine;<&sol;div>&NewLine;<&sol;div>&NewLine;<p>A year after having her eye removed&comma; she learned that the cancer had spread to her liver&comma; killing her by 2014&period; Meredith Legg was two grades below Kenan at Hopewell High School and was also diagnosed in 2009&period;<br &sol;>&NewLine;Meredith&comma; a basketball star at University of South Carolina&comma; died in 2014 at the age of 26&period;<br &sol;>&NewLine;It wasn&&num;8217&semi;t until a third woman from the same high school&comma; 19-year-old Summer Heath&comma; was diagnosed with ocular melanoma that panic began to swirl of a possible cancer cluster&period;<br &sol;>&NewLine;Of the studies conducted&comma; the only commonality has been that the victims lived or worked within a 15-mile radius of Huntersville&period; and three of them on record attended Hopewell High School&comma; albeit&comma; years apart&period;<br &sol;>&NewLine;In the recent case of Jessica Boesmiller&comma; similarly she experienced blurred vision one night in November that lead to the diagnosis of ocular melanoma that was taking up half of her right eye&period;<br &sol;>&NewLine;Jessica was eight months pregnant with twins at the time and like nearly half of the other patients&comma; had a complete removal of the eye&period;<br &sol;>&NewLine;She delivered healthy twins days before Christmas who were found to be cancer-free&period;<&sol;p>&NewLine;<h6><strong><img class&equals;"alignnone wp-image-287828" src&equals;"https&colon;&sol;&sol;konniemoments&period;com&sol;wp-content&sol;uploads&sol;2018&sol;01&sol;Summer-Heath-1&period;png" alt&equals;"Summer Heath 1&period;png" width&equals;"707" height&equals;"681" &sol;>Summer Heath was diagnosed at 19&period; The Hopewell High School alum joins <&sol;strong><strong>nearly two dozen people in the area affected by the eye cancer<&sol;strong><&sol;h6>&NewLine;<p>Researchers have not been able to pinpoint exactly what&&num;8217&semi;s causing the cluster and Dr Michael Brennan&comma; the ophthalmologist leading the efforts&comma; recently said&colon; &&num;8216&semi;In all of our studies we’ve never found an environmental or genetic factor&period;’<br &sol;>&NewLine;Dr Brennan who is leading the study to find what is causing the cancer cluster&comma; received a grant of &dollar;100&comma;000 in April to conduct a geospacial study on patients to find the commonality between them&period; However&comma; no environmental or genetic link has been pinpointed&period;<br &sol;>&NewLine;The retired ophthalmologist in Burlington&comma; has worked to convene medical experts – including specialists from UNC&comma; Duke University and Philadelphia to help guide the Huntersville work&period;<&sol;p>&NewLine;<&sol;div>&NewLine;<p class&equals;"mol-para-with-font">The study is examining 18 patients within a 15-mile radius&comma; 13 of who are women and will follow their geographical history&period;<img class&equals;" alignright" src&equals;"https&colon;&sol;&sol;i0&period;wp&period;com&sol;konniemoments&period;com&sol;wp-content&sol;uploads&sol;2018&sol;01&sol;Michael-Brennan-1&period;png&quest;ssl&equals;1&amp&semi;w&equals;304" alt&equals;"Michael Brennan 1&period;png" &sol;><br &sol;>&NewLine;It well then stretch the boundaries to patients diagnosed 25 miles away&comma; 15 of who are women&period;<br &sol;>&NewLine;This came after tests done on the soil and water at Hopewell High School&comma; where three of the patients attended&comma; came up negative for any harmful toxins&period;<br &sol;>&NewLine;A genetic study later found that there were no hereditary causes for the disease&period;<br &sol;>&NewLine;Ocular melanoma is a malignant tumor in the eye that can spread to other parts of the body and is especially dangerous if it reaches the liver&period; The disease is diagnosed in about 2&comma;500 adults in the US each year&period; Most often it strikes in lightly pigmented individuals with a median age of 55 years&period;<br &sol;>&NewLine;According to the Ocular Melanoma Foundation&comma; if the cancer spreads&comma; there is a 15 percent survival rate and if it does not chances of survival are 80 percent&period;<br &sol;>&NewLine;Nine of the first 12 patients that Dr Brennan studied were female and six younger than 30 years old&period;<br &sol;>&NewLine;This is especially unusual for a cancer that is found mostly in men over 60 with blue eyes&period;<br &sol;>&NewLine;While few of the patients have fit that criteria&comma; two-thirds are young women&comma; leading families and researchers to believe this is more than a coincidence&period;<br &sol;>&NewLine;Brennan was also struck by the number of cases of ocular melanoma in one town&period; He estimates he saw no more than 10 such cases in 40 years of practice&period;<br &sol;>&NewLine;&&num;8216&semi;There is a substantial number of patients in a relatively small area that’s beyond the usual instance&comma;&&num;8217&semi; said Dr Brennan&period;   Brennan doesn’t fault the state’s work in the Huntersville cases&period; But he said some cancer cluster studies overlook key data&comma; such as by using the cities where patients are diagnosed instead of where they lived or worked&period;<br &sol;>&NewLine;&OpenCurlyDoubleQuote;All I’m trying to do is get the smart people to talk to each other&comma;” he said&period; &OpenCurlyDoubleQuote;What we want to do is make this a personal investigation&comma; as well as professional&period; The intent is to bring the consortium back to Huntersville and sit with families and patients and say&comma; here’s what we know and don’t know&period;”<&sol;p>&NewLine;<div class&equals;"artSplitter mol-img-group"><&sol;div>&NewLine;<p class&equals;"mol-para-with-font">&NewLine;<p>&nbsp&semi;<&sol;p>&NewLine;<&sol;div>&NewLine;<&sol;div>&NewLine;<&sol;div>&NewLine;<&sol;div>&NewLine;<&sol;div>&NewLine;

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