Just before noon on Thursday South Pasadena officers and a mental health specialist were called to that location for a welfare check by the woman’s landlord who was concerned about her well-being

Sheriff’s deputies said the 49-year-old woman was suffering from problems of an eating disorder and was having a seizure as officers arrived

They spoke to her for more than 90 minutes and tried to offer medical care
At one point, she became combative and was waving a BB gun around that officers believed to be a semi-automatic handgun
Officers opened fire, she was hit in the torso, and later died at the hospital
Marquez was best known for playing nurse Wendy Goldman on the medical drama ER, starring George Clooney  
Police say they had been to that home on multiple occasions in the past

At around 2pm, police say she grabbed a semiautomatic handgun and pointed it at the officers, prompting them to open fire on her.
As The South Pasadenan first reported, she was struck at least once in the torso and taken to a hospital, where she died of her injuries. However, the woman’s gun that was seized from the house turned out to be a replica of a semi-automatic handgun. Lt Mendoza said.
Police say they had been to Marquez‘s home on many occasions in the past, reported KABC. On Thursday morning, it was the her landlord who summoned them after becoming concerned for her well-being.

Vanessa Marquez.4Marquez [L-R], had been vocal about her many health problems on social media, earlier revealed that she was terminally ill with celiac disease, suffered from pulmonary embolism and seizures 

The Sheriff’s Homicide Bureau has launched an investigation into the officer-involved shooting.
Marquez is best known for playing nurse Wendy Goldman on the popular NBC medical drama ER starring George Clooney between 1994 and 1997.
Last year, Marquez publicly accused the Oscar-winning actor and director of playing helping blacklist her after she spoke out about alleged harassment on the set of ER, including being subjected to racist and sexist remarks.
Clooney responded by insisting that he had no idea Marquez had been blacklisted and had played no part in it.

‘I had nothing to do with casting,’ Clooney said in a statement. ‘I was an actor and only an actor. If she was told I was involved in any decision about her career then she was lied to. The fact that I couldn’t affect her career is only surpassed by the fact that I wouldn’t.’

Vanessa Marquez.3
Marquez hit her career peak on ER. After leaving the show she appeared in three episodes of the sitcom Malcolm in the Middle in 1999, followed by a few more roles in TV films and shorts

Marquez had been vocal on social media about her struggles with various health problems, including what she described as terminal celiac disease, pulmonary embolism, osteoporosis and seizures.
She posted her final status update on Facebook on August 8, accusing Twitter CEO Jack Dorsey of hypocrisy for previously kicking her off Twitter for ‘naming his friend George Clooney at the beginning of the #Metoo movement in October’, but allowing the incendiary InfoWars host and notorious conspiracy theorist Alex Jones to remain on the platform.

Vanessa Marquez' tweet on George Clooney 1.jpgMarquez made headlines in October 2017 when she accused Clooney of helping blacklist her after she spoke out about being harassed on the set of ER

ABC reports on the incident

Marquez was a long-time member of TCM Party – a group of cinephiles passionate about classic movies.
Other members of the group paid tribute to Marquez on twitter Friday.